[Ill after drinking untreated milk; 'die Amelander Krankheit'].
Ned Tijdschr Geneeskd. 2013;157(51):A7078
Authors: Jacobs JJ, Sanderman R
In 2012 three patients consulted their general practitioner with symptoms of gastro-enteritis with bloody stools. This was caused by drinking untreated milk infected with Campylobacter jejuni. Another patient developed reactive arthritis. He too had drunk untreated milk that had probably been infected with Yersinia enterocolitica. Between 1958 and 1995 many German children living in the region of Cologne developed gastro-enteritis after holidaying on Ameland, one of the Dutch islands. This condition was known as ‘die Amelander Krankheit’, and was caused by drinking untreated milk that had been infected with Campylobacter jejuni. After instructions to boil the milk before drinking were followed, the illness disappeared. These cases show that consumption of untreated milk can have negative consequences for health. Hence, if patients develop gastroenteritis symptoms after visiting a farm we recommend that the possibility that they may have drunk untreated milk is taken into account.
PMID: 24345367 [PubMed - indexed for MEDLINE]
Opinions of Dutch Liver Transplant Recipients on Anonymity of Organ Donation and Direct Contact With the Donor’s Family.
Transplantation. 2014 Sep 10;
Authors: Annema C, Op den Dries S, van den Berg AP, Ranchor AV, Porte RJ
BACKGROUND: In the Netherlands, anonymity of organ donation, which is currently protected by legislation, has come under discussion. In the Dutch society, a tendency to allow direct contact between transplant recipients and their donor’s family is noticeable. As little is known about the opinion of Dutch liver transplant recipients on anonymity of organ donation and direct contact with the donor’s family, this study examines their opinions.
METHODS: A cross-sectional study was conducted in 244 liver transplant recipients. Their opinions were examined in relation to demographic, transplant-related and emotional variables. Data were collected by questionnaire. Transplant-related variables were retrieved from the hospital’s liver transplant database.
RESULTS: Fifty-three percent of the respondents (n=177) agreed with anonymity of organ donation, mainly out of respect for the donor. Living situation, age, and level of positive affect influenced this opinion. The majority of the respondents (65%) indicated that they would like to receive some information about their donor, like age, sex, and health status. Only 19% of the respondents favored direct contact with the donor’s family, mainly to express their gratitude personally. Respondents transplanted for alcoholic cirrhosis were less in favor of direct contact. Respondents with feelings of guilt doubted more about direct contact.
CONCLUSION: There is no need to change the current legislation on anonymity of organ donation. However, most liver transplant recipients would like to receive some general information about their donor. Therefore, clear guidelines on the sharing of donor data with recipients need to be established.
PMID: 25211521 [PubMed - as supplied by publisher]
The effects of a problem solving-based intervention on depressive symptoms and HIV medication adherence are independent.
PLoS One. 2014;9(1):e84952
Authors: Gross R, Bellamy SL, Chapman J, Han X, O’Duor J, Strom BL, Houts PS, Palmer SC, Coyne JC
Depression and depressive symptoms predict poor adherence to medical therapy, but the association is complex, nonspecific, and difficult to interpret. Understanding this association may help to identify the mechanism explaining the results of interventions that improve both medical therapy adherence and depressive symptoms as well as determine the importance of targeting depression in adherence interventions. We previously demonstrated that Managed Problem Solving (MAPS) focused on HIV medication adherence improved adherence and viral load in patients initiating a new antiretroviral regimen. Here, we assessed whether MAPS improved depressive symptoms and in turn, whether changes in depressive symptoms mediated changes in adherence and treatment outcomes. We compared MAPS to usual care with respect to presence of depressive symptoms during the trial using logistic regression. We then assessed whether MAPS’ effect on depressive symptoms mediated the relationship between MAPS and adherence and virologic outcomes using linear and logistic regression, respectively. Mediation was defined by the disappearance of the mathematical association between MAPS and the outcomes when the proposed mediator was included in regression models. Although MAPS participants had a lower rate of depressive symptoms (OR = 0.45, 95% confidence interval 0.21-0.93), there was no evidence of mediation of the effects of MAPS on adherence and virological outcome by improvements in depression. Thus, interventions for medication adherence may not need to address depressive symptoms in order to impact both adherence and depression; this remains to be confirmed, however, in other data.
PMID: 24400124 [PubMed - indexed for MEDLINE]
Posted in PLoS One
Tagged J.C. Coyne
Mindfulness training in a heterogeneous psychiatric sample: outcome evaluation and comparison of different diagnostic groups.
J Clin Psychol. 2014 Jan;70(1):60-71
Authors: Bos EH, Merea R, van den Brink E, Sanderman R, Bartels-Velthuis AA
OBJECTIVES: To examine outcome after mindfulness training in a heterogeneous psychiatric outpatient population and to compare outcome in different diagnostic groups.
METHOD: One hundred and forty-three patients in 5 diagnostic categories completed questionnaires about psychological symptoms, quality of life, and mindfulness skills prior to and immediately after treatment.
RESULTS: The mixed patient group as a whole improved significantly on all outcome measures. Differential improvement was found for different diagnostic categories with respect to psychological symptoms and quality of life: Bipolar patients did not improve significantly on these measures. This finding could be explained by longer illness duration and lower baseline severity in the bipolar category.
CONCLUSION: Mindfulness training is associated with overall improvement in a heterogeneous outpatient population. Differences in outcome between diagnostic categories may be ascribed to differences in illness duration and baseline severity.
PMID: 23801545 [PubMed - indexed for MEDLINE]
A critical reanalysis of the relationship between genomics and well-being.
Proc Natl Acad Sci U S A. 2014 Aug 25;
Authors: Brown NJ, MacDonald DA, Samanta MP, Friedman HL, Coyne JC
Fredrickson et al. [Fredrickson BL, et al. (2013) Proc Natl Acad Sci USA 110(33):13684-13689] claimed to have observed significant differences in gene expression related to hedonic and eudaimonic dimensions of well-being. Having closely examined both their claims and their data, we draw substantially different conclusions. After identifying some important conceptual and methodological flaws in their argument, we report the results of a series of reanalyses of their dataset. We first applied a variety of exploratory and confirmatory factor analysis techniques to their self-reported well-being data. A number of plausible factor solutions emerged, but none of these corresponded to Fredrickson et al.’s claimed hedonic and eudaimonic dimensions. We next examined the regression analyses that purportedly yielded distinct differential profiles of gene expression associated with the two well-being dimensions. Using the best-fitting two-factor solution that we identified, we obtained effects almost twice as large as those found by Fredrickson et al. using their questionable hedonic and eudaimonic factors. Next, we conducted regression analyses for all possible two-factor solutions of the psychometric data; we found that 69.2% of these gave statistically significant results for both factors, whereas only 0.25% would be expected to do so if the regression process was really able to identify independent differential gene expression effects. Finally, we replaced Fredrickson et al.’s psychometric data with random numbers and continued to find very large numbers of apparently statistically significant effects. We conclude that Fredrickson et al.’s widely publicized claims about the effects of different dimensions of well-being on health-related gene expression are merely artifacts of dubious analyses and erroneous methodology.
PMID: 25157145 [PubMed - as supplied by publisher]
Depression screening and patient outcomes in pregnancy or postpartum: a systematic review.
J Psychosom Res. 2014 Jun;76(6):433-46
Authors: Thombs BD, Arthurs E, Coronado-Montoya S, Roseman M, Delisle VC, Leavens A, Levis B, Azoulay L, Smith C, Ciofani L, Coyne JC, Feeley N, Gilbody S, Schinazi J, Stewart DE, Zelkowitz P
OBJECTIVE: Clinical practice guidelines disagree on whether health care professionals should screen women for depression during pregnancy or postpartum. The objective of this systematic review was to determine whether depression screening improves depression outcomes among women during pregnancy or the postpartum period.
METHODS: Searches included the CINAHL, EMBASE, ISI, MEDLINE, and PsycINFO databases through April 1, 2013; manual journal searches; reference list reviews; citation tracking of included articles; and trial registry reviews. RCTs in any language that compared depression outcomes between women during pregnancy or postpartum randomized to undergo depression screening versus women not screened were eligible.
RESULTS: There were 9,242 unique titles/abstracts and 15 full-text articles reviewed. Only 1 RCT of screening postpartum was included, but none during pregnancy. The eligible postpartum study evaluated screening in mothers in Hong Kong with 2-month-old babies (N=462) and reported a standardized mean difference for symptoms of depression at 6 months postpartum of 0.34 (95% confidence interval=0.15 to 0.52, P<0.001). Standardized mean difference per 44 additional women treated in the intervention trial arm compared to the non-screening arm was approximately 1.8. Risk of bias was high, however, because the status of outcome measures was changed post-hoc and because the reported effect size per woman treated was 6-7 times the effect sizes reported in comparable depression care interventions.
CONCLUSION: There is currently no evidence from any well-designed and conducted RCT that screening for depression would benefit women in pregnancy or postpartum. Existing guidelines that recommend depression screening during pregnancy or postpartum should be re-considered.
PMID: 24840137 [PubMed - indexed for MEDLINE]
Prevalence of posttraumatic stress disorder (PTSD) in women with breast cancer.
J Psychosom Res. 2014 Jun;76(6):485-6
Authors: Kwakkenbos L, Coyne JC, Thombs BD
PMID: 24840144 [PubMed - indexed for MEDLINE]
Are Patient and Relationship Variables Associated With Participation of Intimate Partners in Couples Research?
Health Psychol. 2014 Aug 18;
Authors: Hagedoorn M, Hein FL, Schulz T, Homan van der Heide JJ, Niesing J, Westerhuis R, Ploeg RJ, Ranchor AV
Background: Recruitment of participants for studies focusing on couples facing illness is a challenging task and participation decline may be associated with nonrandom factors creating bias. This study examines whether patient and relationship characteristics are associated with partner participation in research. Method: Patients invited to participate in a cross-sectional study on adaptation and quality of life after renal transplantation were asked to forward information about an add-on study to their partners. Results: A total of 456 participating patients had a partner; 293 of the partners showed interest in the study and 206 actually completed the questionnaire. Backward logistic regression analyses revealed that demographic, illness, and personal characteristics of the patient were not associated with partner interest in the study nor actual partner participation. However, partners who indicated interest in the study showed more active engagement toward the patients (as reported by the patients). Furthermore, patients of partners who actually completed the questionnaire reported less negative affect and higher relationship satisfaction than patients whose partner did not participate in the study. Discussion: It is encouraging that of the large number of variables tested, only 2 were associated with the participation of partners. Nevertheless, well-functioning couples appear to be overrepresented in our study, calling for specific effort to include marital distressed couples in research focusing on dyadic adaptation to illness. (PsycINFO Database Record (c) 2014 APA, all rights reserved).
PMID: 25133832 [PubMed - as supplied by publisher]
Cognitive therapy for patients with schizophrenia.
Lancet. 2014 Aug 2;384(9941):400
Authors: Coyne JC, van Linschoten HS
PMID: 25088854 [PubMed - indexed for MEDLINE]
Posted in Lancet
Tagged J.C. Coyne
Exploring the response shift phenomenon in childhood patients with cancer and its effect on health-related quality of life.
Oncol Nurs Forum. 2014 Jan 1;41(1):48-56
Authors: Brinksma A, Tissing WJ, Sulkers E, Kamps WA, Roodbol PF, Sanderman R
PURPOSE/OBJECTIVES: To explore the response shift phenomenon in pediatric patients with cancer and to determine its effects on ratings of health-related quality of life (HRQOL).
DESIGN: Retrospective pre- and post-test design.
SETTING: Pediatric oncology department in the northern part of the Netherlands.
SAMPLE: 37 children newly diagnosed with cancer and 80 parents.
METHODS: The then-test method was used to determine response shift. HRQOL was assessed within two weeks postdiagnosis (pretest) and three months later (post-test) using both child and parent reports of PedsQL and Cantril’s ladder. The post-test and then-test were administered concurrently.
MAIN RESEARCH VARIABLES: Overall and multidimensional HRQOL.
FINDINGS: Scores on Cantril’s then-test were lower than the pretest in both child and parent reports, indicating response shift in the assessment of overall HRQOL. Children experienced a greater response shift than parents. No differences were found between the PedsQL then- and pretests.
CONCLUSIONS: Both child- and parent-report ratings of overall HRQOL were affected by response shift, resulting in an underestimation of the improvement in overall HRQOL between diagnosis and three months postdiagnosis. No response shift was demonstrated in the more specific domains of HRQOL (PedsQL).
IMPLICATIONS FOR NURSING: Knowledge of the response shift phenomenon helps nurses to better interpret the outcomes of HRQOL. The use of the PedsQL instrument is recommended in future studies that aim to demonstrate changes in HRQOL.
PMID: 24195842 [PubMed - indexed for MEDLINE]